2. Signaling Pathways
  3. Apoptosis
  4. Bcl-2 Family
  5. Mcl-1 Isoform
  6. Mcl-1 Degrader

Mcl-1 Degrader

Mcl-1 Degraders (2):

Cat. No. Product Name Effect Purity
  • HY-128360
    dMCL1-2
    		Degrader 99.29%
    dMCL1-2 is a potent, selective MCL1 PROTAC degrader based on a Cereblon ligand, with a KD value of 30 nM for binding to MCL1. dMCL1-2 induces ubiquitination and degradation of MCL1. dMCL1-2 degrades MCL1, cleaves Caspase-3, and induces Apoptosis. dMCL1-2 can be used in research related to multiple myeloma.
  • HY-184160
    Mcl1 Degrader-1
    		Degrader
    Mcl1 Degrader-1 is an autophagy-targeting chimera (AUTAC) that selectively degrades the Mcl1 protein. Mcl1 Degrader-1 mediates K63 ubiquitination of Mcl1 via TRAF6/UBC13, transports it to autolysosomes for degradation through p62/SQSTM1, and activates Beclin1-dependent autophagy. Mcl1 Degrader-1 can be used in studies related to multiple myeloma and non-small cell lung cancer.